Boston university yin chong

Making a B-line for transplantation tolerance. Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming. Bacterial infections, alloimmunity, and transplantation tolerance. Transplant Rev Orlando. Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.

Role of bacterial infections in allograft rejection. Expert Rev Clin Immunol. Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice.

Alegre ML, Chong A. Toll-like receptors TLRs in transplantation. Front Biosci Elite Ed. Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance. Memory alloreactive B cells and alloantibodies prevent anti-CDmediated allograft acceptance. Toll-like receptor signaling in transplantation. The multiple facets of toll-like receptors in transplantation biology.

The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele. Long-term control of alloreactive B cell responses by the suppression of T cell help. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.

Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation. Cellular therapies for type 1 diabetes. Horm Metab Res. Expression of complement regulatory proteins in accommodated xenografts induced by anti-alpha-Gal IgG1 in a rat-to-mouse model.

Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice.

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen. TLR engagement prevents transplantation tolerance. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

Concurrent antiviral and immunosuppressive activities of leflunomide in vivo. Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning.

J Exp Med. A mouse model for studying intrahepatic islet transplantation. Evidence that tilapia islets do not express alpha- 1,3 gal: implications for islet xenotransplantation. Mouse-heart grafts expressing an incompatible carbohydrate antigen. Transition from accommodation to tolerance. Skin graft survival in genetically identical cloned pigs. The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection.

IFN-gamma production is specifically regulated by IL in mice made tolerant with anti-CD40 ligand antibody and intact active bone. Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy. Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell tolerance.

Experiences with leflunomide in solid organ transplantation. Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures. J Neurochem. Onset of accumulation of PrPres in murine ME7 scrapie in relation to pathological and PrP immunohistochemical changes. J Comp Pathol.

Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection. Combination of antilymphocyte globulin and leflunomide leads to superior grafts. Transplant Proc. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide.

Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout GT-Ko mice. Anti-galactose-alpha 1,3 galactose antibody production in alpha1,3-galactosyltransferase gene knockout mice after xeno and allo transplantation.

Transpl Immunol. Nondepleting anti-CD4 but not anti-CD8 antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1, 3-galactosyl-transferase knock-out mice. Differential immune response to carbohydrate epitopes on allo- and xenografts: implications for accommodation. Anti-galactose-alpha 1,3 Galactose antibody production in alpha1, 3-galactosyltransferase gene knockout mice after xeno- and allotransplantation.

Tolerance of T-independent xeno-antibody responses in the hamster-to-rat xenotransplantation model is species-restricted but not tissue-specific. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Differential immune responses to alpha-gal epitopes on xenografts and allografts: implications for accommodation in xenotransplantation. CD3 complex-stimulated T cells.

J Biol Chem. The portosystemic shunt protects liver against ischemic reperfusion injury. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide.

In vitro and in vivo antitumor activity of a novel immunomodulatory drug, leflunomide: mechanisms of action. Biochem Pharmacol.

In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression. FK treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation. Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation. Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model.

Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats. Anti-CD4 therapy in combined heart-kidney, heart-liver, and heart-small bowel allotransplants in high-responder rats. Cancer Res. Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.

Leflunomide-based immunosuppression for porcine islet xenotransplantation. Differential effect of leflunomide on concordant xenogeneic islet graft rejection and recurrence of autoimmune diabetes. Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts.

J Pharmacol Exp Ther. Quantitation of the changes in splenic architecture during the rejection of cardiac allografts or xenografts. The immunosuppressive metabolite of leflunomide, A77 , affects murine T cells through two biochemical mechanisms. My lab also has a strong program of collaborative research with Dr. Joel Collier, a bioengineer at Duke University, to develop of nanoparticulate adjuvant-free vaccines that can elicit protective immune responses with minimal inflammation.

Such a vaccine that elicits minimal inflammation may be ideal for tolerant patients, as we now appreciate that inflammation can destabilize established tolerance. Incorporation of sex and gender guidelines into transplantation literature. PMID: Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Nat Commun. Regulation of Alloantibody Responses. Front Cell Dev Biol. Impaired T lymphocyte responses during childhood Staphylococcus aureus infection.

Chou and his capable colleagues and collaborators, this is a work of extremely high quality. No one in the field of Chinese pedagogy can rival Chou's skill, expertise, and experience. First Step is an outstanding, student-friendly primer of beginning Chinese. Professors, teachers, and instructors will find First Step both useful and a source of inspiration.

Click here to download zipped file of all vocabulary audio files. Click here to download zipped file of all workbook audio files.

Illus: 40 color illus. Overview Author s Praise 6 Resources. Emphasis is on basic grammar structure and principles Textbook features both traditional and simplified characters, pinyin, and English translation Perforated workbook which is sold separately facilitates easy handling of homework Free audio recordings of dialogues and other content available online Appropriate for college and high school students.

Chih-p'ing Chou is professor of East Asian studies at Princeton University and director of the university's Chinese language and Princeton in Beijing programs. Jing Wang is senior lecturer in Chinese at Princeton. Jun Lei is a former lecturer in Chinese at Princeton.